Pharmacological profiles and clinical effects of azelnidipine, a long-acting calcium channel blocker.
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چکیده
منابع مشابه
Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan.
The present studies were undertaken to investigate the potential effect of a calcium channel blocker (CCB) to enhance the inhibitory effect of an angiotensin (Ang) II type 1 (AT1) receptor blocker (ARB) on vascular injury and the cellular mechanism of the effect of CCB on vascular remodeling. In polyethylene cuff-induced vascular injury of the mouse femoral artery, proliferation of vascular smo...
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Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملEvaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker
Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...
متن کاملPharmacological Profile of Flunarizine: a Calcium Channel Blocker
Flunarizine is a non selective calcium channel antagonist. It is highly lipophilic compound which distributes preferentially in adipose tissue and passes the blood brain barrier readily. Numerous preclinical and controlled clinical studies, including double blind clinical studies in which the drug was compared with placebo or standard drugs in particular disease showing efficacy in migraine, ve...
متن کاملBenidipine, a long-acting calcium channel blocker, inhibits cardiac remodeling in pressure-overloaded mice.
OBJECTIVE The effects of long-acting calcium channel blockers (CCBs) on pressure overload-induced cardiac remodeling are seldom studied in animals. We evaluated the effects of benidipine, a long-acting CCB, on cardiac remodeling. METHODS Rat neonatal cardiac myocytes were used to examine the influence of benidipine on protein synthesis. Cardiac remodeling was induced in C57 B6/J mice by trans...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2003
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.122.539